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apalutamide will reduce the level or impact of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with medications that are CYP3A4 substrates can result in lower publicity to those remedies.cyclophosphamide will enhance the level or outc